Cosmetic raw material whitening agent, NIACINAMIDE, CAS: 98-92-0

NIACINAMIDE
1. Basic information ‌
Chemical name ‌ : 3-pyridine formamide
Alternative names ‌ : Vitamin B3, nicotinamide, vitamin PP
Chemical formula ‌ : C₆H₆N₂O
Molecular weight ‌ : 122.12 g/mol
CAS No. Youdaoplaceholder0:98-92-0
Appearance ‌ : White crystalline powder, odorless
Solubility ‌ : Readily soluble in water (691g/L, 20 ° C), insoluble in ethanol/acetone
2. Core functions and mechanisms ‌
Whitening and fading spots ‌
Block melanin transport to the epidermis, improve uneven skin tone, fade sunspots and acne marks;
Long-term use is effective for chloasma (with significant effect at 5% concentration).
Control oil and fight acne ‌
Regulate sebum secretion, reduce oiliness, assist in improving enlarged pores;
Anti-inflammatory effects relieve acne redness and swelling.
Barrier repair ‌
Promotes ceramide synthesis, enhances cuticle water retention capacity, improves dryness sensitivity;
Relieve barrier damage problems such as rosacea.
Anti-aging and antioxidant ‌
Stimulate collagen production, reduce free radical damage, delay fine line formation;
Inhibits matrix metalloproteinases (MMPs) to protect collagen structure.
3. Product application and concentration selection ‌
Application form ‌ ‌ Characteristics and recommended concentration ‌
Stock ‌ 2%-10% concentration gradient, use alone or in combination
Essence/lotion ‌ 3%-5% is mainstream (e.g. OLAY White Bottle)
Face cream/Body lotion ‌ 2%-5% balance efficacy and gentleness
Medical repair agent ‌ to assist in pellagra and photoaging

Combination regimen ‌ :

With panthenol: enhances repair effect;
With VC derivatives: Synergistic brightening and antioxidant;
Avoid using with high concentrations of acids (if acid, salicylic acid).
4. Notes ‌
Building tolerance ‌
Initial use is recommended to start with ≤2% concentration and test behind the ear;
Redness and tingling may occur in some people (usually subsides within 1-2 weeks).
Use misconceptions ‌
There is no scientific basis for "NIACINAMIDE causing hair", but it may be related to the manifestation of hair after the skin tone is brightened.
Suitable for pregnant women (no teratogenic evidence), but use with caution in high concentrations for severely sensitive skin.
Regulations & Safety ‌
China has not set a cap on the addition of cosmetics, but ≥5% must be labeled as irritating;
Oral intake limit ≤35mg per day (overdose may cause liver damage).
5. Market representative product ‌
High-end line ‌ : SK-II small light bulb (5% NIACINAMIDE + exclusive active ingredient);
Popular line ‌ : OLAY Pale Spot White Bottle (5% NIACINAMIDE + Acylamine)
Affordable serum ‌ : The Ordinary 10% NIACINAMIDE + zinc (oil control essence);
Body care ‌ : 3% Vaseline NIACINAMIDE Body Lotion (for improving dullness).

Note: The actual effect varies greatly depending on individual skin type, and significant improvement can be seen after continuous use for more than 8 weeks.