HYDROXYACETOPHENONE, a preservative for cosmetic ingredients, CAS No. : 99-93-4
- state
- White needle-like crystals at room temperature， flammable.
- characteristic
- It is readily soluble in hot water， methanol
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1. Basic characteristics 🧪
Physical properties
White needle-like crystals at room temperature, flammable.
It is readily soluble in hot water, methanol, ethanol and other organic solvents, but poorly soluble in petroleum ether.
Natural source
Found in plants of the Compositae family (such as Artemisia capillaris, Artemisia capillaris) and in plants of the Apocynaceae family.
2. Applications in cosmetics 💄
Core functions
Preservative enhancer : As a safe high-temperature stabilizer, it reduces the use of traditional preservatives (such as phenoxyethanol) and extends the shelf life of products.
Antioxidant whitening : Inhibits tyrosinase activity, reduces melanin synthesis, improves pigmentation and brightens skin tone.
Soothing antibacterial : Relieves redness and irritation of the skin, friendly to sensitive skin; Broad-spectrum antibacterial properties help improve skin infections.
Safety
Safety is higher when added to standard, but overdose may irritate sensitive skin, cause contact dermatitis or allergic reactions.
3. Medicinal value 💊
Choleretic effect : Promotes bile secretion and the excretion of bile acids and bilirubin, used as an adjunctive treatment for hepatitis (especially effective in reducing jaundice).
Precautions : Ingest harmful, contact may irritate eyes, respiratory system and skin.
4. Preparation method
Mainstream process : Phenol as raw material, esterification with acetic anhydride to form phenyl acetate, then synthesis through Fries rearrangement reaction, with anhydrous AlCl₃ as the catalyst.
Optimization direction : Recycling intermediate products (such as the o-dichlorobenzene layer) can increase the yield to 51.9%.
5. Other applications
It is widely used in the chemical industry as a spice, dye and organic synthesis intermediate.
📌 Recommendations for Use
Cosmetics selection : Use compliant products first, apply topical tests for sensitive skin.
Risk avoidance : Avoid contact with eyes and mucous membranes, use protective gear for industrial use.
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